Diagnosis and Probability Example
Importance
In this section and example diagnosis and probability will be shown for those who are not able to grasp how a doctor may easily know if their child has SCID. In this diagnosis a Punnett Square will be used to help show all possible allelic combinations of gametes in a cross of parents with known genotypes. It will predict the probability of their offspring possessing certain sets of alleles or in this case Severe Combined Immunodeficiency. An example pedigree will also be shown as a genealogical table of the example family's ancestry and recorded blood types.
Family Information
Client names: Lawrence and Terese Dupree Gene disorder: Severe Combined Immunodeficiency (SCID) Sex of baby: XY Family History: Client: Mother - Terese Dupree, Age 39 (carrier) / Father- Thomas Dupree, Age 39 (normal) Punnett Square
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Pedigree
This Pedigree starts from the Maternal and Paternal Grandparents and continues to the Paternal and Maternal Siblings. As one can see Lawrence and Terese Dupree are connected because they are married. Together they have two children Megan and Jordan and soon to be another child, the child they are testing for SCID. Based on the Pedigree the family and parents can have a good idea that their child will either be normal like Megan or a carrier with SCID, If the X chromosome containing the disease of Terese is given to their child. The reason this information can be established from this Pedigree is because of the genes the clients gave. The Father, Lawrence contained normal XY chromosomes. The Mother was a carrier which means she must have had an x chromosome carrying the genetic disorder. Since she was only a carrier, their new baby will have a 50% chance of being normal or a carrier which inevitably since he is a male tests him positive for SCID.
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Of Course these two examples of a diagnosis are just a small diagnosis that does not 100% tell if the child as SCID. Further technology and tests will have to be given to the child. If a family is curious to know if their child contains a specific genetic disease a Punnett square or a pedigree may help constitute to their curiosity. On the other hand, families who are not just curious but are in need of medical attention and an accurate diagnosis should consult their doctor to do tests.